ABSTRACT
Objetivo: Establecer la asociación entre la edad, sexo, Índice de masa corporal, consumo de bebidas alcohólicas y consumo de cigarrillos con la respuesta inadecuada a la vacuna contra la Hepatitis B, en los pacientes con infección por VIH que fueron atendidos en la Unidad Clínica de Enfermedades Infecciosas y Tropicales del Hospital Regional Docente de Trujillo - Perú, entre 2014-2016. Materiales y métodos: Se realizó un estudio observacional, retrospectivo, de corte transversal, tipo casos y controles. Resultados: De los pacientes vacunados se encontró que la edad ≥ 50 años; con OR=3,4 y el CD4<200, con OR=35,0, son los factores de riesgo para la respuesta inadecuada a la vacuna contra hepatitis B. Conclusiones: Existe asociación entre el recuento de células CD4 <200 y la edad mayor de 50 años con una respuesta Inadecuada a la vacunación contra hepatitis B en pacientes infectados por VIH en el Hospital Regional Docente de Trujillo.
Objective: To establish the relationship among age, sex, body mass index, consumption of alcoholic beverages and cigarettes with the inadequate response to the vaccine against Hepatitis B in patients with HIV infection who were treated in the Clinical Unit of Infectious and Tropical Diseases of the Regional Hospital of Trujillo - Peru, from 2014 to 2015. Materials and methods: The study was observational, retrospective, cross-sectional, type cases and controls. Results: In the vaccinated patients, it was found that the age ≥ 50 years old; with OR = 3.4 and CD4 <200, with OR = 35.0, are the risk factors to get the inadequate response to the vaccine against Hepatitis B. Conclusions: There is a relationship between the re-count of cells CD4 <200 and the age over 50 years old with an Inadequate response to the vaccination against hepatitis B in HIV-infected patients in the Regional Hospital of Trujillo.
ABSTRACT
En esta revisión histórica trataremos de recordar a grandes maestros de la medicina, quienes eran personas íntegras, capacitadas y cultas. Tuvieron la sabiduría de trasmitir su saber y experiencia a muchos de sus discípulos, algunos que incluso continuaron y desarrollaron su obra. Enfatizamos la importancia del padre de la medicina, Hipócrates; el padre de la epidemiologia, a John Snow y su aporte al conocimiento y control del cólera mediante la observación científica; al Dr. Ignor Semelweiss, y su descubrimiento de que la sepsis puerperal era causado por la contaminación de las manos del personal de salud; a los dos padres de la bacteriología moderna: Louis Pasteur y Roberto Koch, y sus numerosos discípulos como el Dr. Eberth, descubridor del agente de la fiebre tifoidea, Loeffler (difteria), Pfeiffer (influenza) y Kitasato (tétanos), en el caso de Koch, y el Dr. Demule Roux, para Pasteur. También hablamos de Sigmund Freud y sus discípulos quienes aportaron y disidieron de sus ideas; del aporte de los doctores Charles Laveran, Patrick Manson y Ronald Ross en el conocimiento de la malaria. En Sudamérica, recordamos al Dr. Oswaldo Cruz, quien en los inicios del siglo 20 combatió las plagas, y su discípulo el Dr. Carlos Chagas, descubridor del mal de Chagas. En el Perú existen numerosos casos notables de maestro y alumno, uno de ellos es el Dr. Hugo Pesce, quien siendo tropicalista y humanista supo trasmitir sus conocimientos a alumnos como el Dr. Hugo Lumbreras, gran maestro de la medicina tropical en el Perú
In this history review we will try to remember great medicine teachers, who were upright, well-trained, and cultivated persons. They were wise enough to transmit their knowledge and experience to many of their disciples, and some of them have continued and even perfected the teachers' work. We emphasize the importance of the Father of Medicine, Hippocrates; the Father of Epidemiology, John Snow and his contribution to the knowledge and control of Cholera through scientific observation; Dr. Igor Semelweiss, who discovered that puerperal sepsis was caused by contaminated hands from healthcare personnel; the two Founding Fathers of modern bacteriology, Louis Pasteur and Robert Koch, as well as their many disciples such as Dr. Eberth, who discovered the causative agent of Typhoid fever; Dr. Loeffler, who discovered the causative agent of diphtheria, Dr. Pfeiffer, discoverer of what he thought was the causative agent of influenza, and Dr. Kitasato, who discovered the causative agent of tetanus, all of them disciples of Robert Koch; and Dr. Demule Roux, a noticeable disciple of Louis Pasteur. We also refer to Dr. Sigmund Freud and his disciples who perfected and some who disagreed with his ideas; the contributions of doctors Charles Laveran, Patrick Manson, and Ronald Ross in the advances in the knowledge of malaria. In South America, we remember the work of Dr. Oswaldo Cruz, who fought against many infectious diseases in the early 20th century, and his famous disciple, Dr. Carlos Chagas, who discovered the disease that now bears his name. In Peru we also have noticeable instances of teacher and disciples, one of them is the case of Dr. Hugo Pesce, who, being a tropical disease specialist and a known humanist, was able to transmit his knowledge to a distinguished student of his, Dr. Hugo Lumbreras, the greatest professor of tropical medicine in Peru